Professorial Fellow

 

 

 

 

 

Address:

ICTM, Department of Chemistry, Studentski trg 12-16, 11000 Beograd
Laboratory 468/I
Telephone: 3336-681
Fax: 2636-061
Mobile phone: +381642378266
E-mail: dopsen@chem.bg.ac.rs

Education:

1987-1992 Diplomirani hemičar, Hemijski fakultet, Univerzitet u Beogradu.
1992-1996 Magistar hemijskih nauka, Hemijski fakultet, Univerzitet u Beogradu
1996-2002 Doktor hemijskih nauka, Hemijski fakultet, Univerzitet u Beogradu

Research Rank:

1999 – 2003 Assistant
2003 – 2007 Scientific Assistant
2007 – 2012 Senior Scientific Assistant
2012 - Professorial Fellow

Memberships:

1995. – Serbian Chemica Society
2007. – American Chemica Society

Professional Experience:

01.11.1998. - Institute of Chemistry, Technology and metalurgy - Department of Chemistry, University of Belgrade
01.11.1994. - 31.10.1998. Forensic Institute, belgrade
01.10.1992. - 31.10.1994. Faculty of Chemistry, University of Beograde

Research Interests:

Field of interest is medicinal and synthetic organic chemistry. During my researches I was directed to organic chemistry of steroids, heterocyclic molecules and condense heteroaromatic systems, like quinolins, benzothiophens and chryzens. Broad field of interest is the chemistry of natural products.

Language Skills: English

Major Projects:

International:
2010.-2013. New Inhibitors of Botulinum Neurotoxins, EAP.SFPP 983638. Co-director projekta (PPD-CoD).
2010.-2014. Second Generation Small Molecule Inhibitors of Botulinum neurotoxins, 5U01AI82051-02. Participant.
2009, 2010. Multi-targeted compounds”, project HHSN261200800001E. Participant.
2004 – 2006. Synthesis of new polar peroxides with antimalarial activity . Participant.

Basic research:
2011 – 2015. Synthesis of aminoquinolins and derivatives as antimalarials botulinum neurotoxine inhibitors, grant No ON172008. Participant.
2011 – 2015. Controle of apikomplex pathogen infection: from new point of action toward prediction, grant No III 41019. Participant.
2011- New Bioactive Molecules Based On Natural Products, SANU. Participant.

Major Publications:

1. S. Nikolić, D. M. Opsenica, V. Filipović, B. Dojčinović, S. Aranđelović, S. Radulović, S. Grgurić-Šipka, „Strong in vitro Cytotoxic Potential of New Ruthenium-Cymene Complexes”, Organometallics, 2015, 34, 3464−3473
2. D. M. Opsenica, J. Radivojević, I. Z. Matić, T. Štajner, S. Knežević-Ušaj, O. Djurković-Djaković and B. A. Šolaja, „Tetraoxanes as inhibitors of Apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii and anti-cancer molecules”, J. Serb. Chem. Soc., 2015, 80, doi:10.2298/JSC150430063O
3. Z. Reljić, M. Zlatović,  A. Savić-Radojević,  T. Pekmezović,  Lj. Đukanović, M. Matić, M. Plješa-Ercegovac, J. Mimić-Oka, D. Opsenica, T.  Simić, Is increased susceptibility to Balkan endemic nephropathy in carriers of common GSTA1 (*A/*B) polymorphism linked with catalytic role of GSTA1 in ochratoxin biotransformation? Serbian case control study and in silico analysis, Toxins, 2014, 6, 2348-2363
4. M. Videnović, D. M. Opsenica, J. C. Burnett, L. Gomba, J. E. Nuss, Ž. Selaković, J. Konstantinović, M. Krstić, S. Šegan, M. Zlatović, R. J. Sciotti, S. Bavari, B. A. Šolaja, Second Generation Steroidal 4-Aminoquinolines are Potent, Dual-Target Inhibitors of the Botulinum Neurotoxin Serotype A Metalloprotease and P. falciparum Malaria, J. Med. Chem., 2014, 57, 4134−4153.
5. S. Šegan, J. Trifković, T. Verbić, D. Opsenica, M. Zlatović , J. Burnett, B. Šolaja, D. Milojković-Opsenica, „Correlation between structure, retention, property, and activity of biologically relevant 1,7-bis(aminoalkyl)diazachrysene derivatives”, J. Pharmaceut. Biomed.Anal., 2013, 72, 231– 239.
6. Dejan M. Opsenica, Bogdan A. Šolaja, “Second-Generation Peroxides: The OZs and Artemisone” in “Treatment and Prevention of Malaria: Antimalarial Drug Chemistry, Action and Use”, Henry M. Staines, Sanjeev Krishna, (Eds.); Series: Milestones in Drug Therapy; Series Editors: Michael J. Parnham, Jacques Bruinvels. Springer, Basel, 2012. ISBN 978-3-0346-0479-6
7. I. Opsenica, V. Filipović, J. E. Nuss, L. M. Gomba, D. Opsenica, J. C. Burnett, R. Gussio, B. A. Šolaja, S. Bavari, „The synthesis of 2,5-bis(4-amidinophenyl)thiophene derivatives providing submicromolar-range inhibition of the botulinum neurotoxin serotype A metalloprotease”, E. J. Med. Chem., 2012, 53, 374-379
8. Ž. Selaković, D. Opsenica, B. Eaton, C. Retterer, S. Bavari, J. C. Burnett, B. A. Šolaja, R. G. Panchal, „A Limited Structural Modification Results in a Significantly More Efficacious Diazachrysene-Based Filovirus Inhibitor”, Viruses, 2012, 4, 1279-1288
9. I. Opsenica, J. C. Burnett, R. Gussio, D. Opsenica, N. Todorović, C. A. Lanteri, R. J. Sciotti, M. Gettayacamin, N. Basilico, D. Taramelli, J. E. Nuss, L. Wanner, R. G. Panchal, B. A. Šolaja, S. Bavari, „A Chemotype That Inhibits Three Unrelated Pathogenic Targets: The Botulinum Neurotoxin Serotype A Light Chain, P. falciparum Malaria, and the Ebola Filovirus”,  J. Med. Chem., 2011, 54, 1157–1169.
10. D. M. Opsenica, B. A. Šolaja, „Antimalarial Peroxides”, J. Serb. Chem. Soc., 2009, 74, 1155-1193
11. B. A. Šolaja, D. Opsenica, K. S. Smith, W. K. Milhous, N. Terzić, I. Opsenica, J. C. Burnett, J. Nuss, R. Gussio, S. Bavari, „Novel 4-Aminoquinolines active against chloroquine-resistant and sensitive P. falciparum strains that also inhibit botulinum serotype A”, J. Med. Chem., 2008, 51, 4388-4391
12. I. Opsenica, D. Opsenica, C. A. Lanteri, L. Anova, W. K. Milhous, K. S. Smith, B. A. Šolaja, „New Chimeric Antimalarials with 4-Aminoquinoline Moiety Linked to a Tetraoxane Skeleton”, J. Med. Chem., 2008, 51, 6216-6219.
13. I. Opsenica, D. Opsenica, K. S. Smith, W. K. Milhous, B. A. Šolaja, “Chemical stability of the peroxide bond enables diversified synthesis of potent tetraoxane antimalarials,” J. Med. Chem. 2008, 51, 2261–2266
14. J. C. Burnett, D. Opsenica, K. Sriraghavan, R. G. Panchal, G. Ruthel, A. R. Hermone, T. L. Nguyen, T. A. Kenny, D. J. Lane, C. F. McGrath, J. J. Schmidt, J. L. Vennerstrom, R. Gussio, B. A. Šolaja, S. Bavari, “A Refined Pharmacophore Identifies Potent 4-Amino-7-chloroquinoline-Based Inhibitors of the Botulinum Neurotoxin Serotype A Metalloprotease”, J. Med. Chem., 2007, 50, 2127-2136.
15. I. Opsenica, N. Terzić, D. Opsenica, G. Angelovski, M. Lehnig, P. Eilbracht, B. Tinant, Z. Juranić, K. S. Smith, Y. S. Yang, D. S. Diaz, P. L. Smith, W. K. Milhous, D. Đoković, and B. A. Šolaja, “Tetraoxane Antimalarials and Their Reaction with Fe(II)”, J. Med. Chem., 2006, 49, 3790-3799.
16. B. A. Šolaja, N. Terzić, G. Pocsfalvi, L. Gerena, B. Tinant, D. Opsenica, W. K. Milhous, “Mixed Steroidal 1,2,4,5-Tetraoxanes: Antimalarial and Antimycobacterial Activity”, J. Med. Chem., 2002, 45, 3331-3336.
17. D. Opsenica, G. Pocsfalvi, Z. Juranić, B. Tinant, J.-P. Declercq, D. E. Kyle, W. K. Milhous, and B. A. Šolaja: "Cholic Acid Derivatives as 1,2,4,5-Tetraoxane Carriers: Structure, Antimalarial and Antiproliferative Activity", J. Med. Chem., 2000, 43, 3274-3282.

Patenti prijave:

1. Bogdan Šolaja, Dejan M. Opsenica, Gabriella Pocsfalvi, Wilbur K. Milhous, Dennis E. Kyle, “Mixed steroidal 1, 2, 4, 5-tetraoxane compounds and methods of making and using thereof”,
2. US 6906098 B2, Pub. Date: 14. jun 2005.; Appl. No.: 10/359,584, Filed: Feb. 7,2003,  Provisional application No. 60/356633, filed on Feb. 9, 2002.
3. PCT, WO 2003/068736 A3, International Publication Date 21 August 2003 (21.08.2003); International Application Number: PCTRJS2003I0035, International Filing Date: 7 February 2003 (07.02.2003.), Priority Data: 601356,633 9 February 2002 (09.02.2002.) US, Published with international search report. Mixed steroidal 1,2,4,5-tetraoxane compounds and methods of making and using thereof. Inventors: Bogdan Solaja, Belgrade (YU); Dejan M. Opsenica, Veljka (YU); Gabriella Pocsfalvi, Napoli (IT); Wilbur K. Milhous, Germantown, MD (US); Dennis E. Kyle, (US). Applicant (for all designated States except US): U.S. ARMY MEDICAL RESEARCH AND MATERIAL COMMAND [USRJS]; 504 Scott Street, Fort Detrick, MD 21702-5012 (US).

Translated Books:

Organic Chemistry: structure and function, 4th edition, K. Peter C. Vollhardt and Neil E. Schore.
Translators: Dr Dejan M. Opsenica and Dr Dragana R. Milić.
Publisher: Data Status, Beograd, 2004.  ISBN 86-7478-007-5.

Study guide and solutions manual for Organic chemistry: Structure and function, 4th edition, Neil E.
Translators: Prof. Dr. Bogdan A. Šolaja and Dr Dejan M. Opsenica.
Publisher: Data Status, Beograd, 2006. ISBN 86-7478-021-0.

Author of textbooks:

1. Praktikum iz Organske hemije, izdavač DataStatus, Beograd 2008. ISBN 978-86-7478-057-2

Additional activities:

1. Sub-editor for Organic chemistry section of the Journal of the Serbian Chemistry Society
2. Member of the Editorial board of the Journal of the Serbian Chemistry Society