University of Belgrade
Institute of Chemistry, Technology and Metallurgy
National Institute of the Republic of Serbia

grb BUUniversity of Belgrade

172002 Design, synthesis and investigation of fullerene based nanomolecular machines

Government of the Republic of Serbia
Ministry of Education, Science and Technological Development

Project type:

Basic Research


2011 - 2014

Project Coordinator:

ICTM University of Belgrade


Faculty of Chemistry University of Belgrade;  ICTM University of Belgrade; Faculty of Pharmacy University of Belgrade

Project Manager:

Dr. Dragana Milić, associate professor, Faculty of Chemistry University of Belgrade

Number of Researchers:


Aim and Scope:

The project proposal includes fullerene based nanomolecular machines design, synthesis, characterization and investigations. The research will be directed toward: 1) synthesis and supramolecular organization investigations of fulleropeptides as nanomolecular machines components; 2) design and synthesis of nanomolecular machines non-fullerenic subunits: platforms for molecular tweezers and baskets, structural components for pseudorotaxanes, rotaxanes and catenanes; 3) fullerene derivatives incorporation into nanomolecular machines subunits in order to obtain hierarchically ordered supramolecular structures; 4) synthesis of fullerene and steroidal derivatives as rotaxane stopers; 5) theoretical investigations of structure-properties relationship and use of molecular modelling in a design of novel structures, potentially able to form ordered supramolecular aggregates; 6) a complete and unambiguous characterization of synthesized compounds by means of modern spectroscopic methods (IR, UV-Vis, MS, NMR, 2D NMR as well as long range and spatial polarization transfer experiments); 7) investigations of supramolecular organization of synthesized compounds, their intermolecular as well as intramolecular non-covalent supramolecular interactions, mobility of nanomolecular machines and their components in various conditions; 8) investigations of a biological activity of obtained supramolecular aggregates and their components.

Major Results:

The synthesis and characterization of fulleropeptide and steroidal molecules and molecular aggregates able to undergo a motion or a hierarchical ordering as a response to an external stimulus. In order to perform a pseudorotaxane to rotaxane transformations, a terminal incorporation of bulky and rigid subunits, such as steroids is designed and synthesized.


  1. Mira Bjelaković, Nina Todorović, Dragana Milić: “An Approach to Nanobioparticles – Synthesis and Characterization of Fulleropeptides”, Eur. J. Org. Chem. 2012, 5291–5300.
  2. Mira S. Bjelaković, Natalija M. Krstić, Dragana R. Milić, Tatjana J. Kop, Koen Robeyns and Vladimir D. Pavlović: “Oxidative 10-membered ring expansion and contraction of stereoisomeric 1(10)-unsaturated and 1,10-epoxy-5-oxo-5,10-secosteroids induced by peracids”, Tetrahedron, 2012, 68, 7479-7488.


Dr. Dragana Milić, Faculty of Chemistry, Studentski trg 12-16, 11158 Belgrade, Serbia, dmilic@chem.bg.ac.rs