University of Belgrade
Institute of Chemistry, Technology and Metallurgy
National Institute of the Republic of Serbia

grb BUUniversity of Belgrade

172009 Computational design, synthesis and biological evaluation of novel heterocyclic compounds as potential inhibitors of tumorogenesis

Ministry of Education and Science of Republic of Serbia

Project type:

Basic research



Project Coordinator:

Faculty of Pharmacy

Realizatori projekta:

Farmaceutski fakultet, IHTM


Faculty of Pharmacy, ICTM

Project Manager:

Prof. dr Vladimir Savić

Number of Researchers:

7 + 2 foreign researchers

Aim and Scope:

Synthesis and computational study of novel heterocyclic compounds and investigation of their anticancer properties.

Major Results:

Synthesis and anticancer properties of aminopyridines and protpberberine derivatives. Synthesis of imidazopyridines. Novel synthesis of allylacetates.


  1. Suren Husinec, Milka Jadranin, Rade Markovic, Milos Petkovic, Vladimir Savic, Nina Todorovic , Palladium Catalysed Synthesis of Allyl Acetates From Allenes, Tetrahedron Lett. 2010, 51, 4066-4068
  2. S.Husinec, R.Markovic, M.Petkovic, V.Nasufovic, V.Savic. A base promoted cyclisation of N-propargyl aminopyridines. Synthesis of imidazo[1,2-a]pyridine derivatives., Org.Lett. 2011, 13, 2286.
  3. S.Husinec, V.Savic, M.Simic, V.Tesevic, D.Vidovic, Annulations of isoquinoline and carboline ring systems: synthesis of 8-oxoprotoberberine derivatives, Tetrahedron Lett. 2011, 52, 2733
  4. Suren Husinec, Milos Petkovic, Vladimir Savic, Milena Simic, Synthesis of Allyl Acetates via Palladium Catalysed Functionalisation of Allenes and1,3-Dienes, Synthesis, 2012, 399-408
  5. S.Eric, S. Ke, T. Barata, T. Solmajer, J. Antic Stankovic, Z. Juranic, V. Savic, M. Zloh, Target fishing and docking studies of the novel derivatives of aryl-aminopyridines with potential anticancer activity, Biorg. Med. Chem. 2012, 20, 5220-5228