Ministry of Education and Science of Republic of Serbia

Project type:

Basic research

Duration

2010-2014

Project Coordinator:

Faculty of Pharmacy

Realizatori projekta:

Farmaceutski fakultet, IHTM

Participants:

Faculty of Pharmacy, ICTM

Project Manager:

Prof. dr Vladimir Savić

Number of Researchers:

7 + 2 foreign researchers

Aim and Scope:

Synthesis and computational study of novel heterocyclic compounds and investigation of their anticancer properties.

Major Results:

Synthesis and anticancer properties of aminopyridines and protpberberine derivatives. Synthesis of imidazopyridines. Novel synthesis of allylacetates.

Publications:

1. Suren Husinec, Milka Jadranin, Rade Markovic, Milos Petkovic, Vladimir Savic, Nina Todorovic , Palladium Catalysed Synthesis of Allyl Acetates From Allenes, Tetrahedron Lett. 2010, 51, 4066-4068
2. S.Husinec, R.Markovic, M.Petkovic, V.Nasufovic, V.Savic. A base promoted cyclisation of N-propargyl aminopyridines. Synthesis of imidazo[1,2-a]pyridine derivatives., Org.Lett. 2011, 13, 2286.
3. S.Husinec, V.Savic, M.Simic, V.Tesevic, D.Vidovic, Annulations of isoquinoline and carboline ring systems: synthesis of 8-oxoprotoberberine derivatives, Tetrahedron Lett. 2011, 52, 2733
4. Suren Husinec, Milos Petkovic, Vladimir Savic, Milena Simic, Synthesis of Allyl Acetates via Palladium Catalysed Functionalisation of Allenes and1,3-Dienes, Synthesis, 2012, 399-408
5. S.Eric, S. Ke, T. Barata, T. Solmajer, J. Antic Stankovic, Z. Juranic, V. Savic, M. Zloh, Target fishing and docking studies of the novel derivatives of aryl-aminopyridines with potential anticancer activity, Biorg. Med. Chem. 2012, 20, 5220-5228

Contacts:

vladimir.savic@pharmacy.bg.ac.rs