University of Belgrade
Institute of Chemistry, Technology and Metallurgy
National Institute of the Republic of Serbia

grb BUUniversity of Belgrade

172032 Structure-activity relationship of newly synthesized biological active compound

Ministry of education, science and technological development

Project type:

Basic Research



Project Coordinator:

Institute of Chemistry, Technology and Metallurgy


Faculty of Chemistry, Belgrade; Faculty of Agriculture, Belgrade; Faculty of Medicine, Belgrade; Institute for Biological Research, Siniša Stanković, Belgrade;, Innovation center of the Faculty of Chemistry, d.o.o, Belgrade

Project Manager:

Sladjana V. Kostic-Rajacic , principal research fellow
Institute of Chemistry, Technology and Metallurgy, Center of Chemistry, Njegoseva 12, 11000 Belgrade

Number of Researchers:


Aim and Scope:

The present research project include three major parts, as follows: 1. The syntheses and chemical characterization of various new compounds, expected to act as dopaminergic-serotonergic receptor ligands, or alternatively as the opioid receptor ligands, particularly NOP receptor antagonists. 2. Pharmacological characterization of the synthesized compounds as the potential ligands, such as the binding activity estimation, determination of the ligand properties including the agonist or the antagonist activity, possible neuroprotective action, as well as the behavioral studies of the laboratory animals. 3. Theoretical modeling, encompassing QSAR analysis, molecular dinamics, ab initio calculations, and docking simulations of ligand-receptor interactions.

Major Results:

• modeling second extracellular loop of dopamine D2 receptor
• optimizing the optimal selectivity and affinity towards specific class of receptors
• confirmed neuroprotective capacity of newly sinthesized ligands
• α1 receptor modelling and testing with previously sinthesized ligands and with literature ligands


  1. Modeling key interactions between the second extracellular loop of the dopamine D2 receptor and arylpiperazine ligands, Sukalovic Vladimir V, Soskic Vukic , Andric Deana B, Roglic Goran M, Kostic-Rajacic Sladjana V , JOURNAL OF THE SERBIAN CHEMICAL SOCIETY, (2012), 77(3), 259-277
  2. The mechanisms responsible for neuroprotective capacity of arylpiperazine dopaminergic ligands against cell death induced by sodium nitroprusside, Ignjatovic Djurdjica S , Vojnovic-Milutinovic Danijela, Nikolic-Kokic Aleksandra L , Slavic Marija, Andric Deana B, Tomic Mirko D, Kostic-Rajacic Sladjana V , EUROPEAN JOURNAL OF PHARMACOLOGY, (2012), 683 (1-3), 93-100
  3. Investigation of Antibacterial Activity of Cinnamyl Derivatives of Arylpiperazine, Novakovic Irena T, Penjisevic Jelena , Sukalovic Vladimir V , Andric Deana B, Roglic Goran M , Kostic-Rajacic Sladjana V, ARCHIVES OF BIOLOGICAL SCIENCES, (2012), 64 (1), 15-20
  4. Interactions of N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-2-aryl-2-yl-acetamides and 1-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-3-aryl-2-yl-ureas with dopamine D-2 and 5-hydroxytryptamine 5HT(1A) receptors, Sukalovic Vladimir V, Ignjatovic Djurdjica S, Tovilovic Gordana, Andric Deana B, Shakib Kaveh, Kostic-Rajacic Sladjana V, Soskic Vukic , BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, (2012), 22 (12), 3967-3972