Ministarstvo prosvete i nauke Republike Srbije
Vrsta projekta:
Osnovna istraživanja
Trajanje projekta
2010-2014
Koordinator projekta:
Farmaceutski fakultet
Realizatori projekta:
Farmaceutski fakultet, IHTM
Rukovodilac projekta:
Prof. dr Vladimir Savić
Broj istraživača:
7 + 2 strana istraživača Tema i cilj projekta:
Sinteza heterocikličnih jedinjenja i proučavanje njihovih antikancerogenih osobina. Primena kompjuterske hemije u proučavanju i predviđanju osobina novosintetisanih heterocikala.
Najznačajniji rezultati:
Sinteza i antikancerogene osobine aminopiridinskih derivata i derivata protoberberina. Sinteza imidazopiridina. Nova sintetska metodologija za dobijanje alilnih acetata.
Publikacije:
- Suren Husinec, Milka Jadranin, Rade Markovic, Milos Petkovic, Vladimir Savic, Nina Todorovic , Palladium Catalysed Synthesis of Allyl Acetates From Allenes, Tetrahedron Lett. 2010, 51, 4066-4068
- S.Husinec, R.Markovic, M.Petkovic, V.Nasufovic, V.Savic. A base promoted cyclisation of N-propargyl aminopyridines. Synthesis of imidazo[1,2-a]pyridine derivatives., Org.Lett. 2011, 13, 2286.
- S.Husinec, V.Savic, M.Simic, V.Tesevic, D.Vidovic, Annulations of isoquinoline and carboline ring systems: synthesis of 8-oxoprotoberberine derivatives, Tetrahedron Lett. 2011, 52, 2733
- Suren Husinec, Milos Petkovic, Vladimir Savic, Milena Simic, Synthesis of Allyl Acetates via Palladium Catalysed Functionalisation of Allenes and1,3-Dienes, Synthesis, 2012, 399-408
- S.Eric, S. Ke, T. Barata, T. Solmajer, J. Antic Stankovic, Z. Juranic, V. Savic, M. Zloh, Target fishing and docking studies of the novel derivatives of aryl-aminopyridines with potential anticancer activity, Biorg. Med. Chem. 2012, 20, 5220-5228